Toxicity issues related to propylene glycol–free melphalan in patients with multiple myeloma undergoing autologous hematopoietic cell transplant (auto-HCT) may be overblown, according to new research.
Generic melphalan contains propylene glycol (PG) as a solvent. After the FDA approved PG-free melphalan (Evomela, Acrotech) in 2016, contradictory reports emerged about its toxicity, said Ko Maung, MD, of Duke Cancer Institute in Durham, N.C.
“At Duke,