Long-term home oxygen therapy offers little benefit for people with milder chronic obstructive pulmonary disease (COPD), according to one of the largest clinical trials ever published of oxygen therapy in patients with moderate oxygen desaturation.
The LOTT (Long-Term Oxygen Treatment Trial) study randomly assigned 738 patients with mild COPD at a total of 47 sites to either supplemental oxygen or no supplemental oxygen (N Engl J Med 2016;375[17]:1617-1627). Moderate oxygen deficiency was