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FEBRUARY 20, 2025

Daratumumab Delays Transition From Smoldering to Active Multiple Myeloma


Originally published by our sister publication Clinical Oncology News

By Ted Bosworth

In a phase 3 trial, the anti-38 monoclonal antibody daratumumab (Darzalex, Johnson & Johnson) substantially delayed or prevented transformation of smoldering to active multiple myeloma (MM).

Compared with active monitoring, daratumumab not only delayed the initiation of first-line MM therapy, but it showed favorable rates of progression-free survival (PFS) and a trend for an overall survival advantage,