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MARCH 1, 2022

CAR T-Cell Therapy Approved for Heavily Pretreated Multiple Myeloma

By Ted Bosworth and David Doolittle

Originally published by our sister publication, Clinical Oncology News

The FDA approved the chimeric antigen receptor T-cell therapy ciltacabtagene autoleucel, or cilta-cel, for the treatment of relapsed/refractory multiple myeloma (RRMM) in patients who have had four or more prior lines of therapy.

The approval of cilta-cel (Carvykti, Legend/Janssen) was based on results of the phase 1b/2 CARTITUDE-1 study, which showed a complete response in more than 80% of